In this article, we review the latest evidence on using biologics in three JIA subtypes: JIA of polyarticular course (pcJIA), enthesitis-related arthritis (ERA), and psoriatic arthritis (PsA).

A study into sacroiliitis in children with enthesitis-related arthritis.

To report the clinical outcomes of adalimumab in treating refractory Behcet’s disease (BD)-related uveitis in paediatric or adolescent patients.

To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA).

Volume. 26
No. 2

February 2021 Issue

The aim of this review is to provide a comprehensive overview of the important findings and overall conclusions of critical landmark clinical trials in the induction and maintenance treatments in adult AAV for the pediatric rheumatologist. 

Unconditioned hematopoietic stem cell transplantation (HSCT) is the recommended treatment for patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency with an HLA-matched sibling donor (MSD) or family donor (MFD).

Recognition of distinct clinical features of anti-MDA5 antibody-positive dermatomyositis and testing for MSA is crucial in patients with skin ulceration and abnormal pulmonary findings of unknown etiology, as prompt diagnosis with early aggressive treatment and anticipation of complications could make a difference in the outcome of this disease with high mortality.

Our case highlights the importance of early recognition and consideration for extracorporeal membrane oxygenation support in patients with a life-threatening presentation, as it was lifesaving for this child who suffered myocardial oedema and ventricular dysfunction.

This group of patients had a low rate of damage accrual, with one of the lowest rates in renal damage when compared to other cohorts reported...

Aseptic meningitis is a known but unusual serious adverse effect of intravenous immunoglobulin (IVIG). It
usually resembles infectious meningitis, which makes its diagnosis challenging. In this report, we present
the case of a five-and-a-half-year-old Chinese girl with juvenile dermatomyositis (JDM) who presented with
signs of meningismus 21 hours after the initiation of IVIG infusion...

In the era of precision medicine, new understanding of the genetic and molecular basis of multisystem immunodysregulatory disorders that lead to autoimmunity and/or autoinflammation is emerging...

Many syndromes are associated with exaggerated inflammation. Children with hyperinflammatory syndromes often present with vague and non-specific symptoms that pose diagnostic and management challenges. The recent literature seems biased towards referring these syndromes only to the multisystem inflammatory syndrome in children (MIS-C) that is associated with COVID-19. The purpose of this paper is to provide an updated narrative review on the pathophysiology, manifestations and management approaches for common hyperinflammatory syndromes.

Up to 70% of patients with Wiskott-Aldrich Syndrome (WAS) develop autoimmune and inflammatory manifestations. Dysregulation of interleukin (IL)-1 may be involved in their pathogenesis, yet there is little evidence on treatment with anti-IL-1 agents in these patients...

May 2024.
1st Edition. 

General practitioners and paediatricians often find it challenging to  assess children with joint complaints. Indeed, arthritis is uncommon in the general paediatric population and often the symptoms children present  with may be vague...

Neuropsychiatric systemic lupus erythematosus
(NPSLE) refers to the neurological and psychiatric
symptoms that are thought to be related to systemic
lupus erythematosus (SLE). NPSLE can be devastating,
responsible for high rates of morbidity and mortality.
It can occur any time in SLE. A recent large cohort
study showed that NPSLE affects up to 25% of patients
with juvenile-onset SLE...

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